Northside Health Library

Lamellar ichthyosis


Lamellar ichthyosis is a rare skin condition that appears at birth and continues throughout a person's life.


Lamellar ichthyosis is passed down through families (inherited). Both parents must have at least one abnormal gene to pass it to their children.


A baby is born with a collodian membrane -- a shiny, waxy layer of skin that sheds within the first 2 weeks of life. Red, scaly skin remains underneath. It resembles the surface of a fish.


Moisturizers containing urea, ammonium lactate, or other alpha-hydroxy acids may help. Also, retinoid medications such as tazarotene may be used on the skin (topically).

Gene therapy to correct the genetic defect may be possible in the future.

Possible Complications

When the collodian membrane is shed, babies are at risk for infection.

Later in life, eye problems may occur because the eyes cannot close completely.


Morelli JG. Disorders of keratinization. In: Kliegman RM, Behrman RE, Jenson HB, Stanton BF, eds. Nelson Textbook of Pediatrics. 18th ed. Philadelphia, Pa: Saunders Elsevier;2007:chap 657.

Review Date: 10/10/2010
Reviewed By: Linda J. Vorvick, MD, Medical Director, MEDEX Northwest Division of Physician Assistant Studies, University of Washington School of Medicine. Also reviewed by Kevin Berman, MD, PhD, Atlanta Center for Dermatologic Disease, Atlanta, GA. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.
The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.

Northside Hospital - Atlanta

1000 Johnson Ferry Road NE
Atlanta, GA 30342
(404) 851-8000

Northside Hospital - Cherokee

450 Northside Cherokee Blvd.
Canton, GA 30115
(770) 224-1000

Northside Hospital - Forsyth

1200 Northside Forsyth Drive
Cumming, GA 30041
(770) 844-3200

Copyright © 2018 Northside Hospital