Lymphofollicular hyperplasia is an increase in the size of the lymph node follicles. These follicles contain normal white blood cells called lymphocytes. Your body produces more lymphocytes to help the lymph nodes prevent bacteria, viruses, and other types of germs from entering the bloodstream.
Armitage JO. Approach to the patient with lymphadenopathy and splenomegaly. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 174.
Powell LD, Baum LG. Overview and compartmentalization of the immune system. In: Hoffman R, Benz EJ Jr, Shattil SJ, et al, eds. Hematology: Basic Principles and Practice. 5th ed. Philadelphia, Pa: Churchill Livingstone Elsevier; 2008:chap 10.
David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine; and Jatin M. Vyas, MD. PhD, Assistant Professor in Medicine, Harvard Medical School, Assistant in Medicine, Division of Infectious Disease, Department of Medicine, Massachusetts General Hospital. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.