Distal refers to sites located away from a reference point. When used in medicine, it refers to parts of the body further away from the center. For example, the hand is distal to the shoulder. The thumb is distal to the wrist. Usually, that reference point is the center or midline of the body.
Distal is the opposite of proximal.
David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.