The third leading cause of cancer-related deaths, colorectal cancer affects more than 130,000 men and women each year. The most common form of colorectal cancer is Hereditary Nonpolyposis Colorectal Cancer (HNPCC).
HNPCC is associated with the following lifetime risks: an 80% risk of colon cancer, a 60% risk of endometrial cancer, a 12% risk of ovarian cancer and a 13% risk of gastric cancer.
In additions, HNPCC is associated with a greatly increased risk of other less common cancers including kidney/urinary tract cancer, biliary tract cancer and small bowel cancer.
HNPCC-related cancers usually develop before age 50. The majority of HNPCC cancers are caused by inherited mutations in either of two specific genes—MLH1 and MSH2. Northside Hospital offers one of the most accurate tests available for identifying mutations in these genes.
If you have already been diagnosed with colorectal or endometrial cancer, genetic susceptibility testing to screen for HNPCC can be valuable to you for several reasons. It can help to determine if you are at increased risk of developing a second cancer of the colon or endometrium. Testing also is important because each child of a parent with an HNPCC gene mutation has a 50/50 chance for inheriting the altered genes. Knowing that you have HNPCC can help determine your risk and your family's risk for other cancers and assist your doctor in recommending appropriate cancer screening measures.
Consider Genetic Testing to screen for Colon Cancer if:
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Hereditary Cancer Program
Center Pointe II
1100 Johnson Ferry Rd., Suite 355
Atlanta, GA 30342
Phone: (404) 851-6284